This e-book explores how multimodal real-world data (RWD) is helping bridge that gap to accelerate discovery and development.
Accelerate research discovery and development with rich clinical and multimodal oncology data
Comprehensive clinico-molecular data for cancer research
Translational cohorts built for evidence demands
ON.Multiomics delivers discovery‑ready, biomarker‑defined patient cohorts designed to hold up under real‑world translational study criteria. It links comprehensive molecular profiling from Caris Life Sciences with longitudinal clinical data from The US Oncology Network to support translational research analysis over time.

Make earlier, more confident assessments about targets, biomarkers and program feasibility using cohorts designed to remain usable under real‑world study criteria
Validate biological signals in clinically meaningful patient populations and assess prevalence, stratification and signal durability without losing cohort integrity
Work with discovery‑ready clinico‑molecular datasets that reduce time spent reconstructing cohorts and validating data before analysis
Understand how molecular signals translate into treatment sequencing, response and resistance beyond controlled trial settings
Translational questions ON.Multiomics is designed to help answer
ON.Multiomics supports translational teams working through high‑stakes questions that require both molecular depth and real‑world clinical context.
- What is the real‑world prevalence of a target or mutation after accounting for treatment history and disease progression?
- How do molecular signals relate to observed treatment response and durability in routine care?
- What resistance mechanisms emerge over time following specific therapies?
- Do biological signals observed early persist across lines of therapy?
- What is the true addressable patient population for a biomarker‑defined therapy in real‑world practice?
- Do biomarker‑defined cohorts remain viable after applying real‑world study criteria?
- How stable are target populations over time based on testing and treatment patterns?
- Can linked molecular and clinical data support refinement of biomarker strategies for development or regulatory planning?
- What is the real‑world prevalence of a target or mutation after accounting for treatment history and disease progression?
- How do molecular signals relate to observed treatment response and durability in routine care?
- What resistance mechanisms emerge over time following specific therapies?
- Do biological signals observed early persist across lines of therapy?
- What is the true addressable patient population for a biomarker‑defined therapy in real‑world practice?
- Do biomarker‑defined cohorts remain viable after applying real‑world study criteria?
- How stable are target populations over time based on testing and treatment patterns?
- Can linked molecular and clinical data support refinement of biomarker strategies for development or regulatory planning?
How translational teams can apply ON.Multiomics in practice
Evaluate targets and biomarkers earlier
Test whether molecular signals hold up in real‑world patient populations before programs advance
Build biomarker‑defined cohorts with confidence
Define clinically meaningful patient populations that remain analyzable as biomarker, treatment and outcome criteria are applied
Analyze response and resistance over time
Assess treatment response, durability and resistance patterns across lines of therapy using longitudinal clinical context
Pressure‑test real‑world feasibility
Determine whether sufficient patient populations exist to support planned research and development efforts earlier in the lifecycle
Many multiomics datasets emphasize molecular depth or raw scale but lose analytical usability once real‑world study criteria are applied. ON.Multiomics is constructed to preserve analyzable patient cohorts after biomarker, treatment and outcome filters are applied.
ON.Multiomics is delivered as predefined, discovery‑ready datasets designed around common translational research needs. Cohorts are structured and linked in advance rather than built as one‑off custom services.
Cohort definition, data linkage and quality checks occur before delivery. Patients included have sufficient molecular and longitudinal clinical context to support real‑world analysis without extensive rework.
ON.Multiomics includes multi‑year clinical data that capture treatment sequencing and clinician‑assessed outcomes, enabling analysis of response and resistance over time in routine oncology care.
Yes. A consistent clinico‑molecular structure allows teams to reuse the dataset across multiple studies without rebuilding cohorts for each new question.
If you’re evaluating clinico‑molecular data for translational research, a focused conversation can help clarify whether ON.Multiomics is the right fit. Our team can walk through cohort characteristics, data coverage and how the dataset is designed to support real‑world translational questions.