Accelerate research discovery and development with rich clinical and multimodal oncology data

Translational cohorts built for evidence demands

ON.Multiomics delivers discoveryready, biomarkerdefined patient cohorts designed to hold up under realworld translational study criteria. It links comprehensive molecular profiling from Caris Life Sciences with longitudinal clinical data from The US Oncology Network to support translational research analysis over time.  

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How does ON.Multiomics preserve cohort usability under real study criteria?

Who is ON.Multiomics built for?
Translational medicine leadership

Make earlier, more confident assessments about targets, biomarkers and program feasibility using cohorts designed to remain usable under realworld study criteria

Validate biological signals in clinically meaningful patient populations and assess prevalence, stratification and signal durability without losing cohort integrity

Work with discovery‑ready clinico‑molecular datasets that reduce time spent reconstructing cohorts and validating data before analysis

Understand how molecular signals translate into treatment sequencing, response and resistance beyond controlled trial settings

Abstract rings of blue and green dots forming a circular data visualization.

Translational questions ON.Multiomics is designed to help answer

ON.Multiomics supports translational teams working through high‑stakes questions that require both molecular depth and real‑world clinical context.

Discovery and biological insight
Discovery and biological insight
Discovery and biological insight
  • What is the real‑world prevalence of a target or mutation after accounting for treatment history and disease progression?
  • How do molecular signals relate to observed treatment response and durability in routine care?
  • What resistance mechanisms emerge over time following specific therapies?
  • Do biological signals observed early persist across lines of therapy?
Development strategy and real‑world feasibility
Development strategy and real‑world feasibility
Development strategy and real‑world feasibility
  • What is the true addressable patient population for a biomarker‑defined therapy in real‑world practice?
  • Do biomarker‑defined cohorts remain viable after applying real‑world study criteria?
  • How stable are target populations over time based on testing and treatment patterns?
  • Can linked molecular and clinical data support refinement of biomarker strategies for development or regulatory planning?
Discovery and biological insight
  • What is the real‑world prevalence of a target or mutation after accounting for treatment history and disease progression?
  • How do molecular signals relate to observed treatment response and durability in routine care?
  • What resistance mechanisms emerge over time following specific therapies?
  • Do biological signals observed early persist across lines of therapy?
Development strategy and real‑world feasibility
  • What is the true addressable patient population for a biomarker‑defined therapy in real‑world practice?
  • Do biomarker‑defined cohorts remain viable after applying real‑world study criteria?
  • How stable are target populations over time based on testing and treatment patterns?
  • Can linked molecular and clinical data support refinement of biomarker strategies for development or regulatory planning?

How translational teams can apply ON.Multiomics in practice

Evaluate targets and biomarkers earlier

Test whether molecular signals hold up in real‑world patient populations before programs advance

Build biomarker‑defined cohorts with confidence

Define clinically meaningful patient populations that remain analyzable as biomarker, treatment and outcome criteria are applied

Analyze response and resistance over time

Assess treatment response, durability and resistance patterns across lines of therapy using longitudinal clinical context

Pressure‑test real‑world feasibility

Determine whether sufficient patient populations exist to support planned research and development efforts earlier in the lifecycle

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Frequently asked questions about ON.Multiomics
How is ON.Multiomics different from other multiomics datasets?

Many multiomics datasets emphasize molecular depth or raw scale but lose analytical usability once real‑world study criteria are applied. ON.Multiomics is constructed to preserve analyzable patient cohorts after biomarker, treatment and outcome filters are applied.

ON.Multiomics is delivered as predefined, discovery‑ready datasets designed around common translational research needs. Cohorts are structured and linked in advance rather than built as one‑off custom services.

Cohort definition, data linkage and quality checks occur before delivery. Patients included have sufficient molecular and longitudinal clinical context to support real‑world analysis without extensive rework.

ON.Multiomics includes multi‑year clinical data that capture treatment sequencing and clinician‑assessed outcomes, enabling analysis of response and resistance over time in routine oncology care.

Yes. A consistent clinico‑molecular structure allows teams to reuse the dataset across multiple studies without rebuilding cohorts for each new question.

Talk to a data expert

If you’re evaluating clinico‑molecular data for translational research, a focused conversation can help clarify whether ON.Multiomics is the right fit. Our team can walk through cohort characteristics, data coverage and how the dataset is designed to support real‑world translational questions.

Related Resources

The missing link in precision oncology

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Unlocking Precision Oncology: The Power of Molecular and EHR Data Integration in Community Oncology Settings

Experts from Caris Life Sciences, Oncology Hematology Care and Ontada discuss how integrated data is driving smarter decisions in oncology across the drug development lifecycle.

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