A Principal Investigator Perspective: Real-world Evidence Is a Powerful Tool in Bolstering Clinical Trials | Ontada

Oncology Data for Commercial & Brand ON.ClinicalDataView ON.Insights Alerts

Oncology Data for HEOR & Research ON.OutcomesView ON.JourneyView

Real-world Research

Ontada's research expertise covers the entire process, from proposal to publication, with clinical support from practicing oncologists acting as principal investigators, research support from Ontada's Medical Office, and researchers with over 350 real-world publication contributions

Ontada Learn Digital Education Meetings & Events Practice-based Education Strategy & Effectiveness

Cancer care usually happens outside of experimental settings, but patient genomic data isn't commonly used to make decisions. Genospace uses patient data from next-generation sequencing to create market reports. Real-world evidence is vital to understanding genomics in cancer progression and therapeutic interaction.

Our thought leaders share expertise, research, and insights in top oncology publications. Join us to stay updated on cancer care advancements.

Keep yourself informed about the most recent news and announcements from Ontada. Discover the latest developments in oncology research and healthcare solutions.

Join Ontada at oncology conferences across the country to see how our data, research, and provider education solutions can help your company advance cancer care

Upcoming Event

SCOPE

Visit Ontada at Booth 635 at the upcoming Summit for Clinical Ops Executives (SCOPE) conference in Orlando on Feb 3 – 6, 2025, to discover our offerings of real-world data, research and provider education.

Ontada, whose name is a combination of “oncology” and “data,” was formed with the vision that transforming cancer care requires speed. Our commitment is to provide the most current evidence in oncology treatment so insights can be generated faster.

Leadership Team

Ontada is on a mission to transform cancer care and improve the lives of patients, setting new standards in the integration of research and clinical practice to generate real-world data, insights and evidence. Meet our team leading the way.

We need smart, ambitious and empathetic people to help us build the future of cancer treatment. Join us on the frontline of oncology innovation.

In this video blog, Dr. Nicholas Robert, chief medical officer, and Dr. Paul Conkling, senior medical director, discuss the role that real-world evidence plays in supporting clinical trials from the viewpoint of a principal investigator.

Here is an outline of the questions they discuss (and corresponding timestamps) so that you can follow along in their conversation:

Can you describe the clinical trial process and the role of a principal investigator (PI) in a study? (0:35)
The role of real-world data (RWD) and real-world evidence (RWE) are becoming increasingly important. A lot of our RWD comes from electronic health records, such as Ontada’s iKnowMed^SM. As a former practicing physician, can you comment on the process of taking care of patients and recording RWD in an EHR? (3:30)
One of the challenges we face in research is in dealing with a small patient subset (e.g., an uncommon cancer or mutation). In your experience as a PI, can you tell us about how we can conduct single-arm trials in this setting and some of the associated challenges? (6:15)
What information is needed to determine if a patient is eligible for a clinical trial? (9:15)
The utility of RWE: Example 1 – using RWD to expand eligibility criteria. (10:59)
The utility of RWE: Example 2 – understanding how an approved therapy is performing in the real world. (12:48)

Categories

top